Histopathological Spectrum of Nephrectomies; a Single Centre Experience of over 14 Years
Abstract
Nephrectomy is conducted either as an open or a laparoscopic procedure for a variety of clinical indications. These include both neoplastic and non-neoplastic conditions, such as the non-functioning kidney. In many patients the final diagnosis is established on the histopathology of the retrieved kidney. In this study, retrospective analysis of data of last 14 years was studied pertaining to the number and indications of nephrectomy at the present study centre. Demographic and clinical details were assessed. Gross and microscopic histopathological details were recorded. Diagnosis was established on the basis of clinical features and histopathology. A total of 638 total nephrectomy specimens were received. Of these, 280 cases were of neoplastic and 358 of non-neoplastic lesions, with a male-to-female ratio of 1.21:1. The age range varied widely according to clinical manifestations. The age range in the present study was 5–84 years. Patients operated for non-neoplastic disorders were younger (mean age: 38.1 years) than those operated for neoplastic disorders (mean age: 54.4 years). Clear renal cell carcinoma (RCC) was the commonest RCC type (150 patients) followed by papillary RCC (51 cases). Nephrectomy is done due to both benign and malignant clinical indications as observed in this study. The most common indication was chronic pyelonephritis with the non-functioning kidney.
Keywords
How to Cite
References
Kundu R, Baliyan A, Dhingra H, Bhalla V, Punia RS. Clinicopathological spectrum of xanthogranulomatous pyelonephritis. Indian J Nephrol. 2019 Mar–Apr;29(2):111–5. 10.10.4103/ijn.IJN_50_18. PMid: 30983751; PMCID: PMC6440323.
Eble JN, Sauter G, Epstein J, Sesterhenn I. (Eds.) World Health Organization classification of tumours, vol. 7: Pathology and genetics of tumours of urinary system and male genital organ, 3rd ed. Geneva, Switzerland: WHO; 2004; 87 p. ISBN-13-978-92-832-2415-0.
Rafique M. Nephrectomy: Indications, complications and mortality in 154 consecutive patients. J Pak Med Assoc. 2007 Jun;57(6):308–11. PMid: 17629234.
Joniau S, Vander Eeckt K, Van Poppel H. The indications for partial nephrectomy in the treatment of renal cell carcinoma. Nat Clin Pract Urol. 2006 Apr;3(4):198–205. 10.10.1038/ncpuro0458. PMid: 16607368.
Ezomike UO, Modekwe VI, Ekenze SO. Paediatric nephrectomy: Patterns, indications and outcome in a developing country. Malawi Med J. 2018 Jun;30(2):94–8. 10.10.4314/mmj.v30i2.8. PMid: 30627336; PMCID: PMC6307073.
Daradka I. Indications for nephrectomy in children: A report on 119 cases. Saudi J Kidney Dis Transpl. 2012 Nov;23(6):1221–6. 10.10.4103/1319-2442.103563. PMid: 23168852.
Beisland C, Medby PC, Sander S, Beisland HO. Nephrectomy—Indications, complications and postoperative mortality in 646 consecutive patients. Eur Urol. 2000 Jan;37(1):58–64. 10.10.1159/000020101. PMid: 10671787.
Chapman D, Moore R, Klarenbach S, Braam B. Residual renal function after partial or radical nephrectomy for renal cell carcinoma. Can Urol Assoc J. 2010 Oct;4(5):337–43. 10.10.5489/cuaj.909. PMid: 20944808; PMCID: PMC2950769.
Bréhier G, Bouvier A, Besnier L Willoteaux S, Nedelcu C, Culty T, et al. Renal function after partial nephrectomy following intra-arterial embolization of renal tumors. Sci Rep. 2020 Dec;10(1):21352. 10.1038/s41598-020-78461-5
Lam NN, Lloyd A, Lentine KL, Quinn RR, Ravani P, Hemmelgarn BR, et al. Changes in kidney function follow living donor nephrectomy. Kidney Int. 2020 Jul;98(1):176–86. 10.10.1016/j.kint.2020.03.034. Epub 2020 May 1. PMid: 32571482.
Aiman A, Singh K, Yasir M. Histopathological spectrum of lesions in nephrectomy specimens: A five-year experience in a tertiary care hospital. J Sci Soc. 2013;40(3):148–54. 10.4103/0974-5009.120058
El Malik EM, Memon SR, Ibrahim AL, Al Gizawi A, Ghali AM. Nephrectomy in Adults: Asir hospital experience. Saudi J Kidney Dis Transpl. 1997;8(4):423–7. Available from: https://www.sjkdt.org/text.asp?1997/8/4/423/39342
Popat VC, Kumar MP, Udani D, Mundra MP, Vora DN, Porecha MM. A study on culprit factors ultimately demanding nephrectomy. Internet J Urol. 2010;7(1):1–8.
Adamson AS, Nadjmaldin AS, Atwell JD. Total nephrectomy in children: A clinicopathological review. Br J Urol. 1992 Nov;70(5):550–3. PMid: 1467864.
Ghalayini IF. Pathological spectrum of nephrectomies in a general hospital. Asian J Surg. 2002 Apr;25(2):163–9. 10.10.1016/S1015-9584(09)60167-6. PMid: 12376239.
Copyright and licence
Copyright (c) 2022 Farhat Abbas, Muzamil Latief, Shahid Wani, Gul Aalmeen, Mohsin Wani, Summyia Farooq
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
