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As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

  • The submission has not been previously published, nor is it before another journal for consideration.
  • Where relevant, appropriate ethics approval and informed consent were obtained, and the study adhered to the institutional/national ethics guidelines for the proper conduct of research.
  • All authors have read this article and agree to submission.
  • I confirm that the materials included in this manuscript do not violate copyright laws. If a copyright violation is brought to the attention of the publisher after publication, the publisher will notify the author for correspondence and it is the responsibility of the authors to settle issues with the copyright holder.
  • The manuscript strictly adheres to the manuscript preparation guidelines, which is found in 'About' the Journal.
  • I/We had full access to all of the data in this study and I/we take complete responsibility for the integrity of the data and the accuracy of the data analysis. If required, all original data will be available for verification.

Please scroll down for manuscript preparation guidelines and submission preparation checklists. If you encounter any problems at any stage of the submission process, please contact editor@jrenhep.com

Please have the following items ready before you begin submission

  1. A cover letter, to be entered under 'comments for editor' in step 1 of the submission process.
  2. Details of three potential reviewers along with their affiliation and email, to be entered under 'comments for editor' in step 1 of the submission process.
  3. The manuscript, prepared and organized based on the guidelines, to be entered in step 2 of the submission process.
  4. Conflict of Interest statement for each author to be entered in step 3 of the submission process.
  5. Original TIFF images (if relevant to your manuscript), to be uploaded separately in step 4 of the submission process. 

If they are ready, the step-by-step submission process is described below.

Instructions for submission 

  • Click the ‘REGISTER’ tab at the header and complete your profile. Remember to tick the 'Confirmation' and ‘Author' box at the end of the registration page.
  • Once the registration is complete you will receive an automated email with your username and password. 
  • Click LOGIN using your username and password. 
  • Click 'New Submission' to start the five-step submission process. Depending on the size of your manuscript, number of authors and the speed of your browser, the entire process may take from 10 to 15 minutes. 

Step 1: 

  • Tick the submission checklists and the copyright notice. Authors retain the copyright. 
  • In ‘Comments for Editor’ section, write a cover letter (can be copied and pasted from another document), addressed to the Editor-in-Chief, explaining the importance of the study. Below the cover letter, include the details (name, affiliation and email) of three potential reviewers. This is mandatory.   
  •  Click ‘save and continue’.

Step 2: 

  • Under ‘Submission File’ browse your document and click the upload button. Ensure that this is a single Microsoft Word document. The time taken to upload depends upon the size of the document and the efficiency of your browser.
  • Once the upload is successful, you will see the following under ‘submission’. 
  • File name: Automatically generated by the system.
  • Original file name: The Actual name of the file you have uploaded.
  • File size: indicates the size of your document.
  • Date uploaded: the date and time of the upload. 
  • Click save and continue.

Step 3: 

  • Fill in the details of the co-authors by clicking the 'add author' tab. As the submitting author, your details will appear by default. 
  • Once all authors have been added, enter the title and abstract. You can cut and paste it from the original manuscript. 
  • Fields for indexing is optional. If relevant, enter the details of contributing and supporting agencies. Click 'save and continue'.

Step 4: 

  • Supplementary files. If you think that supplementary files are essential to convey your message, then upload them here. Include as much detail as possible. Also upload figures (TIFF images) separately here. You can upload multiple files. Click 'save and continue'. 

Step 5: 

  • Click the finish submission tab and you will receive a message confirming your submission. 


These guidelines are based on ICMJE recommendations.

Adhere to the guidelines: Articles that do not adhere to the guidelines will be returned to the authors without peer review, and the authors will be asked to resubmit as a NEW SUBMISSION.

Plagiarism check: Articles that adhere to the guidelines will undergo plagiarism check first. Articles that fail the test will be returned to the authors without peer-review. More information is found at the end of these guidelines. 

Images: Please pay special attention to preparation of images described at the end of these guidelines. 

Permission and copyright: Where relevant, it is the responsibility of the authors to obtain permission from copyright holders, and to ensure that the use of images, data and illustrations in the manuscripts do not violate copyright laws. If a copyright violation in any of the published article is brought to our attention, we will notify the author for correspondence. It is the responsibility of the author(s) to settle issues with the copyright holder.

General: Manuscripts should be written in English using size 12 Arial font. The overall margin should be 2 cm (0.787 inches) with double space between lines. The manuscript should be submitted as a single file Microsoft Word document, with tables and figures inserted after the references. Also upload high resolution TIFF images separately at step 4 of the submission process. Please see below for more information. The page numbers should be included at the bottom right of the document. The guidelines for review articles, case reports, and letter to editor are given at the end. The following are the guidelines for original articles. Arrange the articles in the described order. 

Title page: Title, Author(s), affiliation of the author(s), email of all authors and contact details of the corresponding author with his or her academic title.   

Abstract: No more than 250 words, single paragraph without any references. The abstract should be written in such a way that it conveys the entire message of the article. Below the abstract include a short title (maximum 50 characters including space) and five key words in alphabetical order. 

Introduction: Describe why you are doing what you are doing in the light of the available literature. 

Materials and Methods: Describe each method under separate headings. If relevant, include a statement about ethics approval and ethics approval number. Policy concerning ethics approval is included here. Describe the methods clearly. Mention the number of samples, equipment and chemicals used, and the number of repeats. Include the statistical methods used. Include the catalogue number of antibodies. 

Results: Describe the results obtained and the level of significance. Do not repeat tabulated results in the text. Reference to tables and figures should be made parenthetically in the text, for example (Figure 1 or Table 1). 

Discussion: Describe your findings but ensure that this is not a repeat of the ‘Results’ section. What is novel about your results? How do your results compare or contrast with the existing literature? What is your message for the scientific community? 

Acknowledgements: Acknowledge your colleagues and sources of finance that made this research possible. 

Conflict of interest:  Declare any conflicts of interest that are pertinent to the current manuscript. More information on conflict on interest is given here. If you do not have any conflict of interest then write "The authors declare no potential conflicts of interest with respect to research, authorship and/or publication of this article". 

References: Use Vancouver style. References should be cited in numerical order (in parentheses) in the text and listed in the same numerical order at the end of the manuscript. There are no limits for the number of references. If you use any software to generate references, manually verify that they are accurate and adhere to the requirements. Examples are given below (adapted from Monash University). The best way to ensure accuracy is to download from PubMed.

For journal articles with 1-6 authors, list all authors. 

Format: Author AA, Author BB, Author CC, Author DD. Title of article.  Abbreviated title of journal. Date of publication YYYY Mon DD;volume  number(issue number):page numbers.  

Example: Courthod G, Tucci M, Di Maio M, Scagliotti GV. Papillary renal cell carcinoma: A review of the current therapeutic landscape. Crit Rev Oncol  Hematol. 2015 Oct;96(1):100-12.  

For journal articles with more than 6 authors, add et al. after the sixth author.  

Format: Author AA, Author BB, Author CC, Author DD, Author EE, Author FF,  et al . Title of article. Abbreviated title of journal. Date of publication YYYY Mon  DD;volume number(issue number):page numbers.  

Example: Alves MR, Carneiro FC, Lavorato-Rocha AM, da Costa WH, da Cunha  IW, de Cássio Zequi S, et al. Mutational status of VHL gene and its clinical  importance in renal clear cell carcinoma. Virchows Arch. 2014 Sep;465(3):321-  30.  


Format: Author AA. Title of book. # edition [if not first]. Place of Publication:  Publisher; Year of publication. Pagination.   

Example: Carlson BM. Human embryology and developmental biology. 4th ed.  St. Louis: Mosby; 2009. 541 p.  

Chapter in a book  

Format: Author AA, Author BB. Title of book. # edition. Place of Publication:  Publisher; Year of publication. Chapter number, Chapter title; p. [page  numbers of chapter].  

Example: Speroff L, Fritz MA. Clinical gynecologic endocrinology and infertility.  7th ed. Philadelphia: Lippincott Williams & Wilkins; c2005. Chapter 29,  Endometriosis; p. 1103-33. 

Edited Book 

Format: Editor AA, Editor BB, editors. Title of book. # edition[if not first].  Place of Publication: Publisher; Year. Pagination.  

Example: O'Campo P, Dunn JR, editors. Rethinking social epidemiology:  towards a science of change. Dordrecht: Springer; 2012. 348 p.  

Chapter in an edited book 

Format: Author AA, Author BB. Title of chapter. In: Editor AA, Editor BB,  editors. Title of book. # edition. Place of Publication: Publisher; Year of  publication. p. [page numbers of chapter]. 

Example: Blaxter PS, Farnsworth TP. Social health and class inequalities. In:  Carter C, Peel JR, editors. Equalities and inequalities in health. 2nd ed.  London: Academic Press; 1976. p. 165-78. 

Tables:  All tables should be created with the 'insert table' function of Microsoft Word. Tables in portrait fromat should fit within the page margin (2.54 cm or 1 inch). Tables that are in landscape format will be published as supplementary files. The tables should be cited in numerical order in the text (Table 1, Table 2 etc). Each table should have a table number and a descriptive title above the table. Explanations for abbreviations and levels of significance should be given at the bottom of the table as letters in superscript (for example a, b, c etc), not as symbols (for example @, # etc.). Insert table(s) immediately after the references.

Figures and figure legends: All illustrations are referred to as "Figures" and must be numbered consecutively, for example (Figure 1, Figure 2 etc). Photomicrographs should be high resolution TIFF images (minimum 300 dpi). After creating the images as high-resolution TIFF images, use the 'insert picture' function of the Microsoft Word to insert figures at the end of the article immediately after the tables. Provide figure legends including figure number, a short title and description immediately below each image. Also upload the figures separately at 'step 4' of the submission process. Photomicrographs should have internal scale markers. Symbols, arrows, or letters used in photomicrographs should contrast with the background. Explain the internal scale and identify the method of staining in photomicrographs.

Quality check of images: Do not submit images that are less than 300 dpi. Also, do not submit without checking the quality of the images because it will cause significant delay in processing of the manuscript. Manuscripts will not be sent out to reviewers until good quality images are submitted. There is a simple way to check the quality of the images before submission. After preparing the images, insert them in a Microsoft Word document using the 'insert picture' function. Save the document as a pdf. A good-quality image will be sharper and non-pixelated. Print the image to confirm. A poor-quality image will be pixelated without sharp edges. It will look a blurred or an ‘out of focus’ image. 

Units: Measurements of length, height, weight, and volume should be reported in metric units (meter, kilogram, or liter) or their decimal multiples. Temperatures should be in degrees Celsius. Blood pressure should be in millimeters of mercury.

Abbreviations and Symbols: Use only standard abbreviations. Avoid abbreviations in the title of the manuscript. The spelled-out abbreviation followed by the abbreviation in parenthesis should be used on first mention unless the abbreviation is a standard unit of measurement.

Review articles: The style, title page, abstracts, tables, references and quality of images are similar to the above guidelines. A review article can be between 3000 and 5000 words, excluding the abstract and references. Write an introduction, followed by contents under various subheadings. Do not number the headings. 

Case Reports: The style, title page, abstracts, tables, references and quality of images are similar to the above guidelines. Write the case report under four major headings – introduction, case report, discussion and conclusion. 

Introduction: Write an introduction that provides background information of the case report in light of the available literature. 

Case report: Describe the case in detail. This should be covered under three subheadings – initial presentation, management and outcome. 

Discussion: Write a comprehensive discussion, but ensure that this is not the repeat of the case. What is novel about this case? What are the advantages and disadvantages of the existing paradigm? How does your management strategy compare or contrast with standard of care? What strategies can be employed for better management? 

Conclusion: Summarize the take-home message both in terms of the topic and management.

Letter to editor: Comments about any of the published articles in JRENHEP can be submitted as letter to editor. The word limit is 1000, including abstract and references.

Title: The title should identify that it is a letter to editor and that is about a published article in JRENHEP.

Example title: Letter to editor regarding [insert the short title of the manuscript].

Abstract: Write an abstract, no more than 100 words. abstract.

Body: Write your comments as paragraphs without any headings.

Other guidelines are similar to ‘review articles’.

Editorials are upon invitation only. 

Plagiarism Check: We have partnered with CrossRef to use iThenticate to detect plagiarism. Plagiarism is presenting other people's work or ideas as your own without acknowledging the original source. However, iThenticate gives a 'similarity index', which is the word-by-word copying of materials from previously published literature. We use similarity index to make a decision. Even if the original source was cited, articles with more than 10% similarity index will be returned to the authors without peer review for re-writing. For articles with similarity index between 1-10%, we follow the guidelines of Committee on Publishing Ethics (COPE) on text recycling to make a decision.