Ex vivo Resection for Renal Cancer: Indications and Results in Specific Clinical Scenarios
Main Article Content
Keywords
ex situ liver resection, extracorporeal liver resection, liver autotransplantation
Abstract
To retrospectively evaluate databases for indications and results of “bench surgery technique” in ex vivo or ex situ renal cancer resection as a lost alternative of savage renal function in renal malignancy or benign large tumors.
We retrospectively evaluated PUBMED databases, including studies from 1980 to 2020. Only very few studies had analyzed “ex vivo [and] ex situ renal resection, extracorporeal renal resection, [and] renal autotransplantation.”
Ex vivo renal resection and autotransplantation is the last chance in patients with renal cancer, but manifests numerous difficulties during and after the surgery. However, we noted that in some patients it provided good control over cancer, prevented long-term dialysis, and avoided renal transplantation, thus giving patients a good quality of life.
References
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13. El Tayar AR, Labruzzo C, Haritopoulos K, Hakim NS. Renal artery aneurysm: ex vivo repair and autotransplantation: case report and review of the literature. Int Surg. 2003 Apr-Jun;88(2):61-3. PMID: 12872894.
14. Maughan E, Webster C, Konig T, Renfrew I. Endovascular management of renal artery aneu-rysm rupture in pregnancy—A case report. Int J Surg Case Rep. 2015;12:41–43. https://doi.org/10.1016/j.ijscr.2015.05.011.
15. Pretorian OMM, Tavakoli A, Pararajasingam R, Augustine T. Staged bilateral renal auto-transplantation preserves renal function in a complicated case of reflux nephropathy. NDT Plus. 2010;3(2):148–150, https://doi.org/10.1093/ndtplus/sfp172
16. Chandak P, Kessaris N, Uwechue RU, Abboudi H, Hossain M, Harris F, et al. Successful exci-sion of a suspected mycotic transplant renal artery patch aneurysm with renal allograft autotrans-plantation. Transplantation. 2014;97(3):e25–e26. https://doi.org/10.1097/01.TP.0000438628.75848.9a
17. Bourgi A, Aoun R, Ayoub E, Moukarzel M. Experience with Renal Autotransplantation: Typical and Atypical Indications. Adv Urol. 2018 Mar 26;2018:3404587. doi: 10.1155/2018/3404587. PMID: 29780413; PMCID: PMC5892291.
18. Pettersson S, Brynger H, Henriksson C, Johansson SL, Nilson AE, Ranch T. Treatment of urothelial tumors of the upper urinary tract by nephroureterectomy, renal autotransplantation, and pyelo cystostomy. Cancer, 1984;54(3):379–386. https://doi.org/10.1002/1097-0142(19840801).
19. Holmang S, Johansson SL. Tumours of the ureter and renal pelvis treated with resection and renal autotransplantation: A study with up to 20 years of follow-up. BJU Int. 2005;95(9):1201–1205. https://doi.org/10.1111/j.1464-410X.2005.05505.x.
20. Komiakov BK, Zamiatnin SA, Popov SV, Shlomin VV, Tsygankov AV, Gonchar IS. Extracorporal surgical treatment of patients with renal cell carcinoma. Vestnik Khirurgii Imeni II Grekova, 2013;173(4):53–56.
21. Tran G, Ramaswamy K, Chi T, Meng M, Freise C, Stoller ML. Laparoscopic nephrectomy with autotransplantation: Safety, efficacy and long-term durability. J Urol. 2015;194(3):738–743. https://doi.org/10.1016/j.juro.2015.03.089
22. Aslam MZ, Brown T, Thwaini AA. Ex-vivo renal surgery and auto-transplantation for benign and malignant renal pathologies: Our early evolving experience of three cases. Journal of Clinical Urology2018;11(1): 27–32. Article first published online: May 11, 2017. https://doi.org/10.1177/2051415817709413.
23. Mukamel E, Konichezky M, Engelstein D, Servadio C: Incidental small renal tumors accompa-nying clinically overt renal cell carcinoma. J Urol. 1988;140:22–24. https://doi.org/10.1016/s0022-5347(17)41474-1. PMID: 3379689.
2. Novick AC, Streem S, Montie JE, Pontes JE, Siegel S, Montague DK, et al. Conservative surgery for renal cell carcinoma: A single-center experience with 100 patients. J Urol. 1989;141:835–839. https://doi.org/10.1016/s0022-5347(17)41026-3. PMID: 2926874
3. Morgan WR, Zincke H. Progression and survival after renal conserving surgery for renal cell car-cinoma: Experience in 104 patients and extended follow-up. J Urol. 1990;144:852–857. https://doi.org/10.1016/s0022-5347(17)39608-8. PMID: 2398558.
4. Angermeier KW, Novick AC, Streem SB, Montie JE. Nephron-sparing surgery for renal cell car-cinoma with venous involvement. J Urol. 1990;144:1352–1355. https://doi.org/10.1016/s0022-5347(17)39738-0. PMID: 2231924.
5. Cheng WS, Farrow GM, Zincke H. The incidence of multicentricity in renal cell carcinoma. J Urol. 1991;146:1221–1223. https://doi.org/10.1016/s0022-5347(17)38051-5. PMID: 1942266
6. Novick AC, Gephardt G, Guz B, Steinmuller D, Tubbs RR. Long-term follow-up after partial removal of a solitary kidney. N Engl J Med. 1991;325:1058–1062. https://doi.org/10.1056/NEJM199110103251502
7. Provet J, Tessler A, Brown J, Golimbu M, Bosniak M, Morales P. Partial nephrectomy for renal cell carcinoma: Indications, results, and implications. J Urol. 1991;145:472–476. https://doi.org/10.1016/s0022-5347(17)38371-4.
8. Oldrizzi L, Rugiu C, De Biase V, Maschio G. The solitary kidney: A risky situation for progressive renal damage? Am J Kidney Dis. 1991;17 (Suppll):57–61, PMID: 2024675.
9. Hitchcock R, Kohler J, Duffy PG, Malone PS. Renal autotransplantation—A kidney saving procedure before spinal radiotherapy. Pediatr Hematol Oncol. 1993;10(4):333–335. https://doi.org/10.3109/08880019309029511.
10. Abraham GP, Siddaiah AT, Ramaswami K, George D, Das K. Ex-vivo nephron-sparing surgery and autotransplantation for renal tumours: Revisited. Can Urol Assoc J. 2014;8(9–10):e728–e732. Published online October 22, 2014. http://dx.doi.org/10.5489/cuaj.1775.
11. Gill IS, Uzzo RG, Hobart MG, Streem SB, Goldfarb DA, Noble MJ. Laparoscopic retroperitoneal live donor right nephrectomy for purposes of allotransplantation and autotransplantation. J Urol. 2000 Nov;164(5):1500-4. PMID: 11025691.
12. Meng MV, Freise CE, Stoller ML. Laparoscopic nephrectomy, ex vivo excision and autotransplantation for complex renal tumors. J Urol. 2004;172:461–464. http://dx.doi.org/10.1097/01.ju.0000130668.94919.59.
13. El Tayar AR, Labruzzo C, Haritopoulos K, Hakim NS. Renal artery aneurysm: ex vivo repair and autotransplantation: case report and review of the literature. Int Surg. 2003 Apr-Jun;88(2):61-3. PMID: 12872894.
14. Maughan E, Webster C, Konig T, Renfrew I. Endovascular management of renal artery aneu-rysm rupture in pregnancy—A case report. Int J Surg Case Rep. 2015;12:41–43. https://doi.org/10.1016/j.ijscr.2015.05.011.
15. Pretorian OMM, Tavakoli A, Pararajasingam R, Augustine T. Staged bilateral renal auto-transplantation preserves renal function in a complicated case of reflux nephropathy. NDT Plus. 2010;3(2):148–150, https://doi.org/10.1093/ndtplus/sfp172
16. Chandak P, Kessaris N, Uwechue RU, Abboudi H, Hossain M, Harris F, et al. Successful exci-sion of a suspected mycotic transplant renal artery patch aneurysm with renal allograft autotrans-plantation. Transplantation. 2014;97(3):e25–e26. https://doi.org/10.1097/01.TP.0000438628.75848.9a
17. Bourgi A, Aoun R, Ayoub E, Moukarzel M. Experience with Renal Autotransplantation: Typical and Atypical Indications. Adv Urol. 2018 Mar 26;2018:3404587. doi: 10.1155/2018/3404587. PMID: 29780413; PMCID: PMC5892291.
18. Pettersson S, Brynger H, Henriksson C, Johansson SL, Nilson AE, Ranch T. Treatment of urothelial tumors of the upper urinary tract by nephroureterectomy, renal autotransplantation, and pyelo cystostomy. Cancer, 1984;54(3):379–386. https://doi.org/10.1002/1097-0142(19840801).
19. Holmang S, Johansson SL. Tumours of the ureter and renal pelvis treated with resection and renal autotransplantation: A study with up to 20 years of follow-up. BJU Int. 2005;95(9):1201–1205. https://doi.org/10.1111/j.1464-410X.2005.05505.x.
20. Komiakov BK, Zamiatnin SA, Popov SV, Shlomin VV, Tsygankov AV, Gonchar IS. Extracorporal surgical treatment of patients with renal cell carcinoma. Vestnik Khirurgii Imeni II Grekova, 2013;173(4):53–56.
21. Tran G, Ramaswamy K, Chi T, Meng M, Freise C, Stoller ML. Laparoscopic nephrectomy with autotransplantation: Safety, efficacy and long-term durability. J Urol. 2015;194(3):738–743. https://doi.org/10.1016/j.juro.2015.03.089
22. Aslam MZ, Brown T, Thwaini AA. Ex-vivo renal surgery and auto-transplantation for benign and malignant renal pathologies: Our early evolving experience of three cases. Journal of Clinical Urology2018;11(1): 27–32. Article first published online: May 11, 2017. https://doi.org/10.1177/2051415817709413.
23. Mukamel E, Konichezky M, Engelstein D, Servadio C: Incidental small renal tumors accompa-nying clinically overt renal cell carcinoma. J Urol. 1988;140:22–24. https://doi.org/10.1016/s0022-5347(17)41474-1. PMID: 3379689.
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Aug 10, 2021
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How to Cite
Ex vivo Resection for Renal Cancer: Indications and Results in Specific Clinical Scenarios. (2021). Journal of Renal and Hepatic Disorders, 5(2), 6-9. https://doi.org/10.15586/jrenhep.v5i2.109
Section
Review Nephrology
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Author Biographies
Danilo Coco, Ospedali Riuniti Marche Nord, Pesaro (PU), Italy.
Department of General Surgery, Ospedali Riuniti Marche Nord, Pesaro (PU), Italy.
Silvana Leanza, Carlo Urbani Hospital, Jesi (Ancona) Italy.
Department of General Surgery, Carlo Urbani Hospital, Jesi (Ancona) Italy.