Wnt/β-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis

Main Article Content

Gayatri D. Shirolkar
School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.

Sara Pasic
School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.

Jully Gogoi-Tiwari
School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.

Manoj K. Bhat
National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, India.

John K. Olynyk
Fremantle and Fiona Stanley Hospitals, Perth, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Arun Dharmarajan
School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.

Janina E. E. Tirnitz-Parker
School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; School of Medicine and Pharmacology, University of Western Australia, Fremantle, WA, Australia.

Keywords

chronic liver disease, hepatocellular carcinoma, liver progenitor cells, metabolic syndrome, Wnt/β-catenin signalling

Abstract

Chronic liver diseases (CLDs) are increasing in prevalence and their end-stage complications, namely, cirrhosis, liver failure and hepatocellular carcinoma represent major global challenges. The most common initiators of progressive CLD are viral hepatitis and long-term alcohol abuse as well as steatosis and steatohepatitis. Irrespective of the underlying aetiology, a common feature of CLD is the formation of hepatic ductular reactions, involving the proliferation of liver progenitor cells (LPCs) and their signalling to fibrosis-driving hepatic stellate cells. The Wnt/β-catenin pathway has been found to regulate development, stemness and differentiation, and alterations in its activity have been associated with tumour development. Recent data highlight the role of Wnt/β-catenin signalling in hepatic metabolism, steatosis and cancer, and suggest targeting of this pathway as a promising molecular strategy to potentially inhibit CLD progression and hepatocarcinogenesis.

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Mar 15, 2018

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Wnt/β-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis. (2018). Journal of Renal and Hepatic Disorders, 2(1), 1-9. https://doi.org/10.15586/jrenhep.2018.29
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Vol. 2 No. 1 (2018): Journal of Renal and Hepatic Disorders
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Review Hepatology
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