Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia

Main Article Content

Jan Freeman
Andrew Austin
Ernesto Robalino Gonzaga


sarcopenia, cirrhosis, wasting, end-stage liver disease, muscle


The complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, especially in patients who are awaiting liver transplantation. An understanding of the pathophysiology of muscle protein homeostasis has led to several proposed mechanisms of sarcopenia and the potential to reverse muscle loss. This review discusses the potential mechanisms of sarcopenia and highlights the possible future means of reversing sarcopenia.


Download data is not yet available.
Abstract 222 | PDF Downloads 78 HTML Downloads 85 XML Downloads 0