The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis

Main Article Content

Fatemeh Mohammadzadeh
Vahid Hosseini
Alireza Alihemmati
Maghsod Shaaker
Gholamali Mosayyebi
Masoud Darabi
Amir Mehdizadeh

Keywords

hepatic lipogenesis, hydroxy pyridine, MK-8245, stearoyl-coenzyme A desaturase 1, SCD1

Abstract

Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids. Imbalanced activity of SCD1 has been implicated in fatty liver induction, inflammation and stress. In this review, the role of SCD1 in hepatic development, function and pathogenesis is discussed. Additionally, emerging novel therapeutic agents targeting SCD1 for the treatment of liver disorders are presented.

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